Botox® and Dysport®
Botox and Xeomin are purified chemicals derived from a bacteria called Clostridium botulinum. Botox is manufactured by Allergan and contains Botulinum toxin type A. Xeomin is manufactured by Merz. Botox has a protein attached to it while Xeomin has no additional protein attached to it. Both contain Botulinum toxin type A that relaxes the muscles of expression when injected. Because of less diffusion when injected many clients now prefer Xeomin, but the side effect profile is comparable.
Skin becomes less elastic over time. Repeated frowning and other facial expressions create visible lines and wrinkles. At a normal neuromuscular junction, a nerve impulse triggers the release of acetylcholine, which causes the muscle to contract. Excessive release of acetylcholine at the neuromuscular junction causes overactive contraction of muscles, which over time can cause lines to form. Initially these lines are present during various habitual facial expressions like frowning, smiling, raising eyebrows etc. Those lines that appear during expression are called “Dynamic Expression Lines”. After sometimes these lines would be present even during rest, when no facial expressions are produced. These are called “Static expression lines”. Loss of collagen also could be partly responsible for static lines. Botox works best for the dynamic expression lines, though regular treatments could eventually lessen or even eliminate the static lines.
Botox® is injected into the affected muscles of facial expression.Botox is effective in reducing excessive muscle activity and thus eliminate wrinkles by blocking the release of acetylcholine at the neuro-muscular junction. Botox® is not a permanent cure. The expression lines will gradually return as the Botox is cleared from the body. Most people see the effect within 2-4 days & maximum result is reached by 10 days. The effect of Botox usually last between 3 to 5 months.
Millions of Botox procedures have been performed all over the world and it is considered as one of the safest cosmetic procedures in the world! The cosmetic effect of Botox-A on wrinkles was originally published in the journal Plastic and Reconstructive Surgery in 1989. Canadian husband and wife ophthalmologist and dermatologist physicians, JD and JA Carruthers, were the first to publish a study on Botox-A for the treatment of glabellar frown lines in 1992. Similar effects had reportedly been observed by a number of independent groups. After formal trials, on April 12, 2002, the FDA announced regulatory approval of botulinum toxin type A (Botox Cosmetic) to temporarily improve the appearance of moderate-to-severe frown lines between the eyebrows (glabellar lines). Subsequently, cosmetic use of botulinum toxin type A has become widespread, with many celebrities viewing it as less intrusive and/or artificial than other types of plastic surgery.
Botox is FDA approved for cosmetic use to treat the frown lines between the eyes called “glabellar frown lines” for patients between 18- 65 years of age. All other uses are considered as off-label and is at the discretion of the treating physician. Botox is very effective for treating the expression lines in the forehead and also the crows-feet area. Botox can also be used to give a slight outer eye-brow lift which is a desirable feminine sign of beauty.
While treating patients with hemifacial spasm at Southend Hospital in England in 1993, Khalaf Bushara and David Park were the first to show botulinum toxin injections inhibit sweating. This was the first demonstration of a non-muscular use of Botox-A. Bushara further showed the efficacy of botulinum toxin in treating hyperhidrosis (excessive sweating). Botox is now an FDA approved treatment for Hyperhydrosis that helps control excessive sweating by temporarily blocking chemical signals from the nerves that stimulate sweat glands. When the sweat glands do not receive chemical signals to sweat – the amount of sweating is reduced. Self-confidence is increased when excessive sweating is finally under control, with no more embarrassment in public and business situations. 100 units of Botox Cosmetic is injected through a very small needle, into the skin of each underarm. The treatment will hinder the nerve endings of the motor endplates. The Botox injections will not only cease the excessive sweating, but it will also provide a simultaneous disappearance of the bad odor associated with the excessive sweating. As with cosmetic treatments, the results from Botox are not permanent. Results will start to appear during the first few weeks after treatment. You will be able to enjoy up to 6-8 months (or longer) of dryness, and reduced odor. After this time period, a repeat Botox Cosmetic treatment will be necessary.
People with the following conditions should not have Botox cosmetic treatment: Known previous allergy to Botulinum Toxin/Botox, Lou Gehrig’s Disease, Disorder of the Peripheral Nerves that Cause Movement (motor nerves), Myasthenia Gravis, Progressive Muscle Weakness with Cancer, Condition where One Object Appears as Two or More Objects (Diplopia/Double Vision), Blurred Vision, Botulinum Food Poisoning due to improperly canned or preserved food, Drooping of the Upper Eyelid, Infection of Lung from Inhaling Stomach Contents, Significant Decrease in Lung Function, Voice Disorder, Hoarseness, Difficulty or Trouble Breathing, Difficulty Swallowing, Problems with Bladder Control, Feeling Weak
Our physician will evaluate you first with medical history and assess the extent of muscular activity producing the expression lines and also photographs so the appropriate dose of Botox can be calculated. For both underarms approximately 100 units of Botox will be required. Our clients pay only for the amount of Botox used and hence it varies from person to person. For underarm sweating you may be able to get reimbursement from the health insurance. However we do not direct